|SkinDNA ™ Gene Descriptor||Genotype||Description|
|AA||Responsible for controlling serum glucose levels, energy intake and release. While glucose is a vital cellular fuel, if not fully metabolised Glycation can occur.
Chromosome Location: 1q31
Glycation has been described as carmelization of the skin from the inside out. The skin-damaging effects of glycation cause wrinkles, dryness (eczema), skin laxity, as well as acne and rosacea.
Advanced Glycation End Products (A.G.Es) are the end result of a glucose-driven process known as Glycation. Glycation occurs when excess bodily glucose molecules link to the skin’s Collagen and Elastin fibers. This cross-linking can form chemical bridges between these proteins. Glycated fibers can become rigid, less elastic and have reduced regenerative ability, which can lead to damage such as laxity, cracking and thinning skin.
In young skin, the Dermal Epidermal Junction has the appearance of a mountain range that helps anchor the Epidermis to the Dermis, forming a network of supportive Collagen fibers.
The genes that make up your Wrinkling (A.G.E.) score play a key role in skin Glycation. They are responsible for controlling serum glucose levels, energy intake and energy release. Having variations in these genes can alter the functioning of normal glucose levels and energy metabolism. While glucose is a vital cellular fuel, if not completely metabolised by the body Glycation can occur, leading way to wrinkling, dryness and laxity.
Collagen is the principle structural protein that holds the skin together.
Collagen is just one of thousands of different proteins in the body. The most abundant protein is collagen. In fact, collagen makes up more than one third of all protein in the body and about 75% of the skin.
Elastin is a protein found in connective tissue that is elastic.
In the skin, Elastin helps keep flexibility by providing a bounce-back reaction if skin is pulled or pinched.
Enough elastin in the skin means that the skin will return to its normal shape after a pull or a pinch. It also helps keep skin smooth as it stretches to accommodate normal activities like flexing a muscle or opening and closing the mouth to talk or eat.
Glucose is the body's prime source of fuel for generating energy.
It is a type of sugar that comes from digesting carbohydrates into a chemical that we can easily convert to energy.
But glucose has its dark side. If not properly metabolised Glucose can bind tightly to proteins and form abnormal chemical bridges that progressively damage tissue elasticity. This process is referred to as Glycation.
Glycation occurs when excess bodily glucose molecules link to the skin's Collagen and Elastin fibers.
This cross-linking can form chemical bridges between these proteins. Glycated fibers can become rigid, less elastic and have reduced regenerative ability, which can lead to damage such as laxity, cracking and thinning skin.