• DISCOVER if you are a carrier of this genetic skin trait.


Firmness + Elasticity

1 in 3 people have a genetic variation that predisposes their skin to accelerated collagen breakdown.

The SkinDNA ™ Genetic Test can help identify if you are a carrier of key genetic variations associated with accelerated collagen loss - even before the signs have become visible.


Keeping the skin firm, plump and wrinkle-free, Collagen is the principle structural protein of the skin. Like many components of the body, collagen undergoes continuous turnover, being produced and recycled on an ongoing basis throughout your life. When you are younger, your body makes more collagen than it loses, but after about the age of 40, collagen loss can accelerate, leading to a decline in the health and appearance of your skin.

Our genetic predispositions play a big role in determining both the speed of collagen production and breakdown. Key variations in this genetic category can identify if the rise and fall of collagen is in balance, or if the breakdown of collagen predominates, which can result in the appearance of premature wrinkling, aging and sagging of the skin.

SkinDNA Collagen Breakdown | MMP1 Skin Enzyme | one of the Genes Tested in the SkinDNA Genetic Test. SkinShift Skincare by Dr Ruthie Harper uses our technology also
Genetic Markers SkinDNA ™ Test for in this category.

Gene Table

SkinDNA ™ Gene Descriptor Genotype Description
s700298/
Collagen Breakdown
1G1G Involved in slowing the breakdown and degradation of Collagen fibers found in the extracellular matrix of human tissue.
Chromosome Location: 11q21-q22
s706371/
Collagen Protection
TT Assists in protecting existing collagen from unnecessary degradation and aids in normalising skin cell functions disrupted by oxidative stress including MMP-1 production
Chromosome Location: 3q21.3
Develop a better understanding about SkinDNA ™ Genetic Test: Firmness + Elasticity category.

Background Science

Keeping the skin firm, plump and wrinkle-free, Collagen is the principle structural protein of the skin. Our genetic predispositions play a big role in determining both the speed of collagen production and breakdown.


The Dermis of the skinSandwiched between the epidermis and hypodermis lies one the skin’s lifeblood area, the dermis. The dermis contains blood vessels that nourish the skin, and structural proteins like collagen that keep the skin firm, plump, and wrinkle-free. As we age our bodies struggle to replenish stores of collagen, and some people are genetically primed to break down collagen faster than others.

It is well established that collagen is an important element of human skin; in fact it is the principle structural protein holding the skin together. Representing 75% of the skin’s dry weight it keeps the skin firm, plump and wrinkle-free. The quantity and quality of the Collagen plays a major role in the skin’s appearance.

Like many components of the body, Collagen undergoes continuous turnover: new Collagen is continually produced and recycled throughout life. At a younger age, the synthesis of Collagen predominates, whereas after about the age of 40, the degradation of Collagen picks up speed4. This degradation process is precipitated by a protein called Matrix Metallopeptidase-1 (MMPs) or Collagenase.


Youthful Skin by SkinDNA Genetic Skin TestIn healthy, youthful skin, the synthesis and degradation of Collagen is in balance: damaged or redundant Collagen is degraded while the deficit is replenished by the ongoing synthesis.

Unfortunately, this intricate balance gets disrupted when there is an oversupply of MMP1: too little of the matrix is synthesized and too much is degraded. The more this occurs the more winkles, roughness and sagginess one tends to have. MMP levels are known to increase with age as a result of photo aging as well as natural aging.

The genes in this category are involved in slowing the breakdown and degradation of Collagen Fibers found in the extracellular matrix of human tissue. Key variations tested in this category can identify if the synthesis and degradation process of Collagen is in balance, or if the degradation predominates (increased MMP levels) that can result in the appearance of premature wrinkling, loss of youthful looks and other ageing skin traits.

Not sure what some words mean? Our glossary may help you

Glossary


Collagen

Collagen is the principle structural protein that holds the skin together.
Collagen is just one of thousands of different proteins in the body. The most abundant protein is collagen. In fact, collagen makes up more than one third of all protein in the body and about 75% of the skin.


Protein

Protein are the building blocks of life. They are essential in helping to build the human body including muscle, bone, blood and collagen.
Protein enables the body to function properly. They are used in all sorts of ways: to transport nutrients and oxygen to vital organs including the skin, and are essential tools needed for cellular repair.


MMP's

Matrix Metalloproteinases (MMP) are critical players in the skin's physiology.
They break down damaged or worn out structural proteins, facilitate the second phase of wound healing, clear pathways for movement of immune cells to infected areas, and so forth.

MMP's are also involved in the breakdown and degradation of the collagen fibrils found in the extracellular matrix of human tissue