Sensitivity + Inflammation
4 in 5 people have a genetic variation that can cause an over reactive inflammation response.
Genetic variations found in vital genes can lead to excessive inflammation - one of the most common themes in early onset aging.
Ever wonder why your skin becomes sensitive in the winter? Or why your skin breaks out in the heat? How about developing skin rash or rosacea after applying perfumes or skincare? Many of these redness and sensitivity issues are instigated by your bodies first primal defence - inflammation.
Your genetic predispositions play a big role in determining the supply, or the over-supply of inflammation production. Key variations tested in this category can identify numerous over-reactive inflammatory mechanisms that cause skin irritations.
Gene Table
| SkinDNA ™ Gene Descriptor | Genotype | Description |
|---|---|---|
| s100286/ Acute Inflammation |
GG | Responsible for signalling the release of inflammatory proteins to help defend skin cells against invaders.
Chromosome Location: 6q21.3 |
| s706371/ Internal Toxins Protection |
AA | Involved in efficiently detoxifying toxic compounds so that they can be safely metabolised and converted to water. Chromosome Location: 11q13 |
| s100921 s100922/ Dermal Sensitivty |
TT AA |
Regulates the detoxification of Epoxides found in pollutions and chemicals into more water soluble so that they can be safely broken down. Chromosome Location: 1q42.1 |
Background Science
The regulation of inflammation and sensitivity concerns are largely controlled by your genes.
Sometimes the body can over compensate and release too many inflammatory proteins to take care of an issue that only required fewer - as a result to body begins to over-react to anything and everything! Soon the body begins to think that that perfume is a virus and that skincare product is going to cause damage - this type of sensitivity is not good as the trauma caused by a constant over supply of inflammation dramatically ages the skin.
Excessive inflammation is one of the most common themes in early onset skin aging. While it is a helpful response in the short term, if inflammation continues on-going, it can play a negative role. Often subtle, the signs include skin sensitivity, redness and irritation.
Genetic variations in this category can be used to identify weather you are at risk great risk of too much inflammation production causing unnecessary trauma to skin cells. The results of excessive inflammation include prolonged irritation, increased redness, and enhanced sensitivity to environmental pollutants and everyday chemicals.
Glossary
Epoxides
Chemical compounds which cause trauma and damage to skin cells.
They can set the foundation for free radical havoc, increase cellular damage, cause collagen to breakdown and enhance skin sensitivity.
These chemical compounds can stem from air pollution, cigarette smoke and exhaust fumes.
Polycyclic Aromatic Hydrocarbons (PAH's)
Highly toxic chemical compounds.
Released from everyday pollutants such as the burning of wood, coal, diesel, and waste, industrial activities, exhaust fumes and cigarette smoke.
Xenobiotics
Harmful toxins that are found in pollutants such as PAHs. These harmful toxins surround us in our day to day living.
If not broken down epoxides can be extremely harmful to the body releasing a wave of free radical mayhem.